This ROI request seeks to obtain approval for structure files to be co-submitted with the revised version of the paper on the archaeal lipid enzyme G1P dehydrogenase. The paper “Structure and evolution of the archaeal lipid synthesis enzyme sn-glycerol-1-phosphate dehydrogenase” has recently been examined by three referees/editors for PNAS (http://www.pnas.org/) accepted for resubmission. The paper has already been approved through the NZAGRC portal and has been assigned an ROI number of 000321 (http://www.nzagrc.org.nz/my-roi,id,321.html). Most of the reviewer’s concerns related not to the structures themselves (which were thought to represent a worthy advance) but the phylogenetic arguments and speculation about the timing of the evolution of the enzyme. The manuscript has been revised to take in these concerns and all the points raised by the three editors answered point-by-point.
Similar to the previously approved manuscript for Mch (The Crystal Structure of Methenyltetrahydromethanopterin Cyclohydrolase from Methanobrevibacter ruminantium: Implications for substrate binding of N5-formyl-5,6,7,8-tetrahydro-methanopterin). This submission also requires that the structure files that detail the structures be submitted so that PDB codes (http://www.rcsb.org/pdb/home/home.do; http://deposit.rcsb.org/) can be assigned. The deadline for resubmission so that the manuscript is not treated as a new submission (which would require re-reviewing the manuscript) is Oct 18th.
