Since this ROI was created a new version of the paper was sent that is sufficient ready for the ROI process.  I was unable to delete the earlier version.  Please use the documents (main paper and supplemental information) labelled "Draft for ROI" for further processing.  Note that there are still minor edits to occur before it is finalised before submission to the journal but there is unlikely to be any opportunity to pass the manuscript through the ROI process between that finalisation and submission. 

Sorry guys - someone had already sent the old version back to me.  This one (the files labelled DraftForROI 4April ..." comprise the version for release approval.  Note that the French partner is likely to submit this in a few days (I don't have control here) so any alternations as soon as possible please.