This paper is based on the structure of the first peptide ligase to be characterised for archaeal pseudomurein biosynthesis. Bioinformatic analyses (taxonomic distribution and gene operon analysis) suggest that the bacterial cell wall biosynthesis and pseudomurein biosynthesis (found in rumen methanogens and other thermophilic methanogens) are evolutionarily-linked.
The PGGRC has supported students involved earlier in the project a few years ago. All other funding came from a Marsden grant.
