Hello

These tables are summaries of what was identified during screens in both the GPLER 1 and 2 projects.

There are five tables for the GPLER 1 and four for the GPLER 2. In the GPLER 1 program the two main libraries screened were the 'Chembridge 5000' diverse chemistry set and a 5000 compound library, also with diverse chemistry, called Actiprobe. In addition, there is an extra table that shows results from 'quantitative-structure-activity-relationship (QSAR) data for the most active compounds. Furthermore, there are two more tables, the results of which were reported in 2013 in quarterly reports, but are included here as well.

For the GPLER 2 there are four tables showing: the Apex library screen with circa 1300 compounds (GPLER2 Apex-library RiV summary table - 22 04 2016); QSAR work done on 'sugar-nitro- hit (GPLER2 Apex-Sugar Nitro derivatives 17 05 2016); fragment library (circa 3200) compounds(GPLER2 FRAGMENT + abm4 + RiV confirmation ALL WORK DONE  19 07 2016); and the natural compound ENZO library (GPLER2 natural ENZO product inhibitor summary table - 28 07 2016). 